RapamycinFungusV1, Main, Exploration, bibRecord, 000258

Programmed longevity, youthspan, and juventology.

Identifieur interne : 000258 ( Main/Exploration ); précédent : 000257; suivant : 000259

Programmed longevity, youthspan, and juventology.

Auteurs : Valter D. Longo [États-Unis, Italie]

Source :

Aging cell [ 1474-9726 ] ; 2019.

RBID : pubmed:30334314

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Animaux (MeSH), Cyclic AMP-Dependent Protein Kinases (antagonistes et inhibiteurs), Espérance de vie (MeSH), Facteur de croissance IGF-I (antagonistes et inhibiteurs), Hormone de croissance (antagonistes et inhibiteurs), Humains (MeSH), Jeune adulte (MeSH), Jeûne (physiologie), Longévité (génétique), Nutriments (physiologie), Radicaux libres (effets indésirables), Rajeunissement (physiologie), Restriction calorique (MeSH), Ribosomal Protein S6 Kinases (antagonistes et inhibiteurs), Régime pauvre en protéines (MeSH), Saccharomyces cerevisiae (métabolisme), Sirolimus (pharmacologie), Souris (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Sérine-thréonine kinases TOR (antagonistes et inhibiteurs).
MESH :
- antagonistes et inhibiteurs : Cyclic AMP-Dependent Protein Kinases, Facteur de croissance IGF-I, Hormone de croissance, Ribosomal Protein S6 Kinases, Sérine-thréonine kinases TOR.
- effets indésirables : Radicaux libres.
- génétique : Longévité.
- métabolisme : Saccharomyces cerevisiae.
- pharmacologie : Sirolimus.
- physiologie : Jeûne, Nutriments, Rajeunissement.
- Adulte, Adulte d'âge moyen, Animaux, Espérance de vie, Humains, Jeune adulte, Restriction calorique, Régime pauvre en protéines, Souris, Sujet âgé, Sujet âgé de 80 ans ou plus.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Animals (MeSH), Caloric Restriction (MeSH), Cyclic AMP-Dependent Protein Kinases (antagonists & inhibitors), Diet, Protein-Restricted (MeSH), Fasting (physiology), Free Radicals (adverse effects), Growth Hormone (antagonists & inhibitors), Humans (MeSH), Insulin-Like Growth Factor I (antagonists & inhibitors), Life Expectancy (MeSH), Longevity (genetics), Mice (MeSH), Middle Aged (MeSH), Nutrients (physiology), Rejuvenation (physiology), Ribosomal Protein S6 Kinases (antagonists & inhibitors), Saccharomyces cerevisiae (metabolism), Sirolimus (pharmacology), TOR Serine-Threonine Kinases (antagonists & inhibitors), Young Adult (MeSH).
MESH :
- chemical , adverse effects : Free Radicals.
- chemical , antagonists & inhibitors : Cyclic AMP-Dependent Protein Kinases, Growth Hormone, Insulin-Like Growth Factor I, Ribosomal Protein S6 Kinases, TOR Serine-Threonine Kinases.
- genetics : Longevity.
- metabolism : Saccharomyces cerevisiae.
- chemical , pharmacology : Sirolimus.
- physiology : Fasting, Nutrients, Rejuvenation.
- Adult, Aged, Aged, 80 and over, Animals, Caloric Restriction, Diet, Protein-Restricted, Humans, Life Expectancy, Mice, Middle Aged, Young Adult.

Abstract

The identification of conserved genes and pathways that regulate lifespan but also healthspan has resulted in an improved understanding of the link between nutrients, signal transduction proteins, and aging but has also provided evidence for the existence of multiple "longevity programs," which are selected based on the availability of nutrients. Periodic fasting and other dietary restrictions can promote entry into a long-lasting longevity program characterized by cellular protection and optimal function but can also activate regenerative processes that lead to rejuvenation, which are independent of the aging rate preceding the restricted period. Thus, a "juventology"-based strategy can complement the traditional gerontology approach by focusing not on aging but on the longevity program affecting the life history period in which mortality is very low and organisms remain youthful, healthy, and fully functional.

DOI: 10.1111/acel.12843
PubMed: 30334314
PubMed Central: PMC6351819

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000432
to stream Main, to step Curation: 000432

Le document en format XML

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<term>Animaux (MeSH)</term>
<term>Cyclic AMP-Dependent Protein Kinases (antagonistes et inhibiteurs)</term>
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<term>Sirolimus (pharmacologie)</term>
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<term>Insulin-Like Growth Factor I</term>
<term>Ribosomal Protein S6 Kinases</term>
<term>TOR Serine-Threonine Kinases</term>
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<term>Hormone de croissance</term>
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<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Caloric Restriction</term>
<term>Diet, Protein-Restricted</term>
<term>Humans</term>
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<term>Espérance de vie</term>
<term>Humains</term>
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<term>Restriction calorique</term>
<term>Régime pauvre en protéines</term>
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<front><div type="abstract" xml:lang="en">The identification of conserved genes and pathways that regulate lifespan but also healthspan has resulted in an improved understanding of the link between nutrients, signal transduction proteins, and aging but has also provided evidence for the existence of multiple "longevity programs," which are selected based on the availability of nutrients. Periodic fasting and other dietary restrictions can promote entry into a long-lasting longevity program characterized by cellular protection and optimal function but can also activate regenerative processes that lead to rejuvenation, which are independent of the aging rate preceding the restricted period. Thus, a "juventology"-based strategy can complement the traditional gerontology approach by focusing not on aging but on the longevity program affecting the life history period in which mortality is very low and organisms remain youthful, healthy, and fully functional.</div>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Programmed longevity, youthspan, and juventology.

Programmed longevity, youthspan, and juventology.

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